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Article

Brain transcriptome-wide association studies in diverse ancestral populations reveal genes implicated in an anxiety-related phenotype.

G3 (Bethesda, Md.) - 7 Jan 2026

Sharma Maya Z, Wheeler Heather E

Abstract excerpt

Anxiety is the most prevalent form of mental illness in the United States. We aimed to identify genetic variation underlying anxiety in diverse ancestral populations through integrating genomic and brain transcriptomic data. We analyzed genome-wide association study (GWAS) summary statistics, using the "Worrier/Anxious Feelings" phenotype from Pan-UK Biobank. We identified 67 independent significant loci in the...

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PMID: 41243181
DOI: 10.1093/g3journal/jkaf277
PMCID: PMC12774604

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