Article
A major role for common genetic variation in anxiety disorders.
Molecular psychiatry - 1 Dec 2020
Purves Kirstin L, Coleman Jonathan R I, Meier Sandra M, Rayner Christopher, Davis Katrina A S, Cheesman Rosa, Bækvad-Hansen Marie, Børglum Anders D, Wan Cho Shing, Jürgen Deckert J, Gaspar Héléna A, Bybjerg-Grauholm Jonas, Hettema John M, Hotopf Matthew, Hougaard David, Hübel Christopher, Kan Carol, McIntosh Andrew M, Mors Ole, Bo Mortensen Preben, Nordentoft Merete, Werge Thomas, Nicodemus Kristin K, Mattheisen Manuel, Breen Gerome, Eley Thalia C
Abstract excerpt
Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (ncase = 25 453, ncontrol = 58 113) and an additional analysis of Current Anxiety Symptoms (ncase = 19 012, ncontrol = 58 113). The liability scale common variant heritability estimate for Lifetime Anxiety Disorder was 26%, and for Current...
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