Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole-exome DNA sequencing in childhood anxiety disorders identifies rare de novo damaging coding variants.

Depression and anxiety - 1 Jun 2022

Olfson Emily, Lebowitz Eli R, Hommel Grace, Pashankar Neha, Silverman Wendy K, Fernandez Thomas V

Abstract excerpt

BACKGROUND: Genetic factors contribute to the development of anxiety disorders, yet few risk genes have been previously identified. One genomic approach that has achieved success in identifying risk genes in related childhood neuropsychiatric conditions is investigations of de novo variants, which has yet to be leveraged in childhood anxiety disorders. METHODS: We performed whole-exome DNA sequencing in 76...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety Disorders
Share to Biological Products

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 35312124
DOI: 10.1002/da.23251
PMCID: PMC9246845

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole-exome DNA sequencing in childhood anxiety disorders identifies rare de novo damaging coding variants.PMID 35312124Read ↗

Ultra-rare<i>de novo</i>damaging coding variants are enriched in attention-deficit/hyperactivity disorder and identify risk genesSemantic proximity Read ↗

Identification of novel rare variants for anxiety: an exome-wide association study in the UK Biobank.Semantic proximity Read ↗

Rare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes.Semantic proximity Read ↗

De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism.Semantic proximity Read ↗

Whole exome sequencing in ADHD trios from single and multi-incident families implicates new candidate genes and highlights polygenic transmission.Semantic proximity Read ↗

Common and rare genetic variants explain distinct diagnostic variance in pediatric attention deficit hyperactivity disorder.Semantic proximity Read ↗

De novo damaging coding mutations are strongly associated with obsessive-compulsive disorder and overlap with autismSemantic proximity Read ↗

Identification of novel genomic loci for anxiety symptoms and extensive genetic overlap with psychiatric disordersSemantic proximity Read ↗

Mutation burden analysis of six common mental disorders in African Americans by whole genome sequencing.Semantic proximity Read ↗

Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study.Semantic proximity Read ↗

At-Risk Genomic Findings for Pediatric-Onset Disorders From Genome Sequencing vs Medically Actionable Gene Panel in Proactive Screening of Newborns and ChildrenSemantic proximity Read ↗

Evaluating rare variants in complex disorders using next-generation sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.