Article
Acute Lymphoblastic Leukemia with Myeloid Mutations Is a High-Risk Disease Associated with Clonal Hematopoiesis.
Blood cancer discovery - 1 May 2024
Saygin Caner, Zhang Pu, Stauber Jacob, Aldoss Ibrahim, Sperling Adam S, Weeks Lachelle D, Luskin Marlise R, Knepper Todd C, Wanjari Pankhuri, Wang Peng, Lager Angela M, Fitzpatrick Carrie, Segal Jeremy P, Gharghabi Mehdi, Gurbuxani Sandeep, Venkataraman Girish, Cheng Jason X, Eisfelder Bart J, Bohorquez Oliver, Patel Anand A, Umesh Nagalakshmi Sheethal, Jayaram Savita, Odenike Olatoyosi M, Larson Richard A, Godley Lucy A, Arber Daniel A, Gibson Christopher J, Munshi Nikhil C, Marcucci Guido, Ebert Benjamin L, Greally John M, Steidl Ulrich, Lapalombella Rosa, Shah Bijal D, Stock Wendy
Abstract excerpt
Myeloid neoplasms arise from preexisting clonal hematopoiesis (CH); however, the role of CH in the pathogenesis of acute lymphoblastic leukemia (ALL) is unknown. We found that 18% of adult ALL cases harbored TP53, and 16% had myeloid CH-associated gene mutations. ALL with myeloid mutations (MyM) had distinct genetic and clinical characteristics, associated with inferior survival. By using single-cell...
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