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Article

The KIR repertoire of a West African chimpanzee population is characterized by limited gene, allele, and haplotype variation.

Frontiers in immunology - 1 Jan 2023

de Groot Natasja G, Heijmans Corrine M C, van der Wiel Marit K H, Bruijnesteijn Jesse, Bontrop Ronald E

Abstract excerpt

Introduction: The killer cell immunoglobulin-like receptors (KIR) play a pivotal role in modulating the NK cell responses, for instance, through interaction with major histocompatibility complex (MHC) class I molecules. Both gene systems map to different chromosomes but co-evolved during evolution. The human KIR gene family is characterized by abundant allelic polymorphism and copy number variation. In contrast,...

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Share to DNA Copy Number Variations
Share to Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hominidae

Share to Killer Cells, Natural

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Identifiers

PMID: 38149259
DOI: 10.3389/fimmu.2023.1308316
PMCID: PMC10750417

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