IL‑1β, IL‑10, and TNF‑α gene polymorphisms are associated with cytokine levels and hepatocellular carcinoma risk in a Chinese cohort.

Abstract excerpt

Chronic hepatic inflammation, driven by factors including viral hepatitis and metabolic dysfunction, is a well-established precursor to hepatocellular carcinoma (HCC). The paper aimed to explore the concerted effects of germline polymorphisms in pivotal cytokine genes and their consequent impact on systemic and local inflammatory profiles in HCC pathogenesis. We conducted a hospital-based, retrospective...

Topics

• Aged
• Female
• Humans
• Male
• Middle Aged
• Carcinoma, Hepatocellular
• Case-Control Studies