Article
Immune infiltration, aggressive pathology, and poor survival outcomes in RECQL helicase deficient breast cancers.
Neoplasia (New York, N.Y.) - 1 Jan 2024
Lashen Ayat, Al-Kawaz Abdulbaqi, Jeyapalan Jennie N, Alqahtani Shatha, Shoqafi Ahmed, Algethami Mashael, Toss Michael, Green Andrew R, Mongan Nigel P, Sharma Sudha, Akbari Mohammad R, Rakha Emad A, Madhusudan Srinivasan
Abstract excerpt
RECQL is essential for genomic stability. Here, we evaluated RECQL in 449 pure ductal carcinomas in situ (DCIS), 152 DCIS components of mixed DCIS/invasive breast cancer (IBC) tumors, 157 IBC components of mixed DCIS/IBC and 50 normal epithelial terminal ductal lobular units (TDLUs). In 726 IBCs, CD8+, FOXP3+, IL17+, PDL1+, PD1+ T-cell infiltration (TILs) were investigated in RECQL deficient and proficient...
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