Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic Signatures Predict the Immunogenicity of BRCA-Deficient Breast Cancer

26 Mar 2019

Abstract excerpt

Abstract Purpose: Breast cancers with BRCA1/2 alterations have a relatively high mutational load, suggesting that immune checkpoint blockade may be a potential treatment option. However, the degree of immune cell infiltration varies widely, and molecular features contributing to this variability remain unknown. Experimental Design: We hypothesized that genomic signatures might predict immunogenicity in BRCA1/2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30914433
DOI: 10.1158/1078-0432.ccr-18-0468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic Signatures Predict the Immunogenicity of BRCA-Deficient Breast CancerPMID 30914433Read ↗

Molecular intrinsic subtypes, genomic, and immune landscapes of BRCA-proficient but HRD-high ER-positive/HER2-negative early breast cancersSemantic proximity Read ↗

Molecular intrinsic subtypes, genomic and immune landscapes of BRCA-proficient but HRD-high ER-positive/HER2-negative early breast cancersSemantic proximity Read ↗

Homologous recombination deficiency and host anti-tumor immunity in triple-negative breast cancerSemantic proximity Read ↗

Immunogenomic Landscape in Breast Cancer Reveals Immunotherapeutically Relevant Gene Signatures.Semantic proximity Read ↗

Pan-cancer analysis reveals homologous recombination deficiency score as a predictive marker for immunotherapy responders.Semantic proximity Read ↗

Enhanced immune response outperform aggressive cancer biology and is associated with better survival in triple-negative breast cancerSemantic proximity Read ↗

Clinical Impact of Tumor DNA Repair Expression and T-cell Infiltration in Breast CancersSemantic proximity Read ↗

Clustering of HR + /HER2- breast cancer in an Asian cohort is driven by immune phenotypes.Semantic proximity Read ↗

Clustering of HR+/HER2- breast cancer in an Asian cohort is driven by immune phenotypesSemantic proximity Read ↗

The Great Immune Escape: Understanding the Divergent Immune Response in Breast Cancer SubtypesSemantic proximity Read ↗

The genomic landscape of breast cancer and its interaction with host immunitySemantic proximity Read ↗

Impact of Typical Somatic Gene Mutation Characteristics on Homologous Recombination Deficiency in Breast Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.