Article
Multi-omics portrait of ductal carcinoma in situ in young women.
Breast cancer research and treatment - 1 Jul 2024
Hong Ruoxi, Cao Boyang, Chen Dongshao, Wu Wei, Luo Tian, Lv Dian, Zhang Weimin, Wang Shusen, Shao Kang
Abstract excerpt
BACKGROUND: Young patients with breast ductal carcinoma in situ (DCIS) often face a poorer prognosis. The genomic intricacies in young-onset DCIS, however, remain underexplored. METHODS: To address this gap, we undertook a comprehensive study encompassing exome, transcriptome, and vmethylome analyses. Our investigation included 20 DCIS samples (including 15 young-onset DCIS) and paired samples of normal breast...
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