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Ectoine Globally Hypomethylates DNA in Skin Cells and Suppresses Cancer Proliferation

29 Nov 2023

Abstract excerpt

Epigenetic modifications, mainly aberrant DNA methylation, have been shown to silence the expression of genes involved in epigenetic diseases, including cancer suppression genes. Almost all conventional cancer therapeutic agents, such as the DNA hypomethylation drug 5-aza-2-deoxycytidine, have insurmountable side effects. To investigate the role of the well-known DNA protectant (ectoine) in skin cell DNA...

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PMID: 38132942
DOI: 10.3390/md21120621

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