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Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin

15 Apr 2015

Abstract excerpt

BACKGROUND: Aging and sun exposure are the leading causes of skin cancer. It has been shown that epigenetic changes, such as DNA methylation, are well established mechanisms for cancer, and also have emerging roles in aging and common disease. Here, we directly ask whether DNA methylation is altered following skin aging and/or chronic sun exposure in humans. RESULTS: We compare epidermis and dermis of both...

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PMID: 25886480
DOI: 10.1186/s13059-015-0644-y

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