Article
Evolutionary Trajectories to Antibiotic Resistance.
Annual review of microbiology - 8 Sept 2017
Hughes Diarmaid, Andersson Dan I
Abstract excerpt
The ability to predict the evolutionary trajectories of antibiotic resistance would be of great value in tailoring dosing regimens of antibiotics so as to maximize the duration of their usefulness. Useful prediction of resistance evolution requires information about (a) the mutation supply rate, (b) the level of resistance conferred by the resistance mechanism, (c) the fitness of the antibiotic-resistant mutant...
Topics
- Anti-Bacterial Agents
- Bacteria
- Drug Resistance, Bacterial
- Evolution, Molecular
- Genetic Fitness
- Genetics, Microbial
- Molecular Biology
- Mutation