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Article

Translational approaches targeting the p53 pathway for anti-cancer therapy.

British journal of pharmacology - 1 Jan 2012

Essmann Frank, Schulze-Osthoff Klaus

Abstract excerpt

The p53 tumour suppressor blocks cancer development by triggering apoptosis or cellular senescence in response to oncogenic stress or DNA damage. Consequently, the p53 signalling pathway is virtually always inactivated in human cancer cells. This unifying feature has commenced tremendous efforts to develop p53-based anti-cancer therapies. Different strategies exist that are adapted to the mechanisms of p53...

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Identifiers

PMID: 21718309
DOI: 10.1111/j.1476-5381.2011.01570.x
PMCID: PMC3268188

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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