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Midlife insulin resistance, APOE genotype, and change in late-life brain beta-amyloid accumulation - A 5-year follow-up [11C]PIB-PET study.

Neurobiology of disease - 1 Jan 2024

Pietilä Elina, Snellman Anniina, Tuisku Jouni, Helin Semi, Viitanen Matti, Jula Antti, Rinne Juha O, Ekblad Laura L

Abstract excerpt

We studied if midlife insulin resistance (IR) and APOE genotype would predict brain beta-amyloid (Aβ) accumulation and Aβ change in late-life in 5-year follow-up [11C]PIB-PET study. 43 dementia-free participants were scanned twice with [11C]PIB-PET in their late-life (mean age at follow-up 75.4 years). Participants were recruited from the Finnish Health2000 study according to their HOMA-IR values measured in...

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Identifiers

PMID: 38123104
DOI: 10.1016/j.nbd.2023.106385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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