Article
Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease.
Annals of internal medicine - 6 Aug 2002
Kivipelto Miia, Helkala Eeva-Liisa, Laakso Mikko P, Hänninen Tuomo, Hallikainen Merja, Alhainen Kari, Iivonen Susan, Mannermaa Arto, Tuomilehto Jaakko, Nissinen Aulikki, Soininen Hilkka
Abstract excerpt
BACKGROUND: Presence of the apolipoprotein E (apoE) epsilon4 allele, which is involved in cholesterol metabolism, is the most important genetic risk factor for Alzheimer disease. Elevated midlife values for total cholesterol level and blood pressure have been implicated recently as risk factors for Alzheimer disease. OBJECTIVE: To study the relative importance and the putative relationship among the apoE epsilon4...
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