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Article

Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults.

Diabetes care - 1 Feb 2013

Willette Auriel A, Xu Guofan, Johnson Sterling C, Birdsill Alex C, Jonaitis Erin M, Sager Mark A, Hermann Bruce P, La Rue Asenath, Asthana Sanjay, Bendlin Barbara B

Abstract excerpt

OBJECTIVE: Insulin resistance dysregulates glucose uptake and other functions in brain areas affected by Alzheimer disease. Insulin resistance may play a role in Alzheimer disease etiopathogenesis. This longitudinal study examined whether insulin resistance among late middle-aged, cognitively healthy individuals was associated with 1) less gray matter in Alzheimer disease-sensitive brain regions and 2) worse...

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Identifiers

PMID: 23069842
DOI: 10.2337/dc12-0922
PMCID: PMC3554303

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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