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Article

Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study.

Neurology - 30 Nov 2010

Schrijvers E M C, Witteman J C M, Sijbrands E J G, Hofman A, Koudstaal P J, Breteler M M B

Abstract excerpt

OBJECTIVE: Diabetes mellitus has been associated with an increased risk of Alzheimer disease (AD), but how it exerts its effect remains controversial. Possible pathophysiologic mechanisms are glucose toxicity and a direct effect of insulin on amyloid metabolism. Most studies had short follow-up,...

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Identifiers

PMID: 21115952
DOI: 10.1212/WNL.0b013e3181ffe4f6
PMCID: PMC3014236

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21115952-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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