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Article

Midlife insulin resistance, APOE genotype, and late-life brain amyloid accumulation.

Neurology - 27 Mar 2018

Ekblad Laura L, Johansson Jarkko, Helin Semi, Viitanen Matti, Laine Hanna, Puukka Pauli, Jula Antti, Rinne Juha O

Abstract excerpt

OBJECTIVE: To examine whether midlife insulin resistance is an independent risk factor for brain amyloid accumulation in vivo after 15 years, and whether this risk is modulated by APOE ε4 genotype. METHODS: This observational study examined 60 elderly volunteers without dementia (mean age at baseline 55.4 and at follow-up 70.9 years, 55.5% women) from the Finnish population-based, nationwide Health2000 study with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29476033
DOI: 10.1212/WNL.0000000000005214
PMCID: PMC5880630

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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