Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

37 Years of Body Mass Index and Dementia: Effect Modification by the APOE Genotype: Observations from the Prospective Population Study of Women in Gothenburg, Sweden.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Bäckman Kristoffer, Joas Erik, Waern Margda, Östling Svante, Guo Xinxin, Blennow Kaj, Skoog Ingmar, Gustafson Deborah R

Abstract excerpt

BACKGROUND: Overweight and obesity in mid- and late-life may increase risk for dementia, whereas a decline in body weight or body mass index (BMI) and underweight in years preceding a clinical dementia diagnosis are also associated with dementia. Little is known about the modifying effect of the APOE genotype, a major susceptibility gene for Alzheimer's disease (AD), on the BMI-dementia adult life course...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Mass Index

Share to Body Weight

Share to Dementia

Share to Follow-Up Studies

Share to Risk Factors

Share to Sweden

Source

Identifiers

PMID: 26402098
DOI: 10.3233/JAD-150326

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

37 Years of Body Mass Index and Dementia: Effect Modification by the APOE Genotype: Observations from the Prospective Population Study of Women in Gothenburg, Sweden.PMID 26402098Read ↗

Age-dependent effects of body mass index across the adult life span on the risk of dementia: a cohort study with a genetic approach.Semantic proximity Read ↗

Extension of Mendelian Randomization to Identify Earliest Manifestations of Alzheimer Disease: Association of Genetic Risk Score for Alzheimer Disease With Lower Body Mass Index by Age 50 Years.Semantic proximity Read ↗

Association of genetic risk score for Alzheimer's disease with late-life body mass index in all of us: Evaluating reverse causation.Semantic proximity Read ↗

Body mass index decline and cognitive trajectories in mild cognitive impairment: the role of maternal history of Alzheimer’s diseaseSemantic proximity Read ↗

Five-Year Change in Body Mass Index Predicts Conversion to Mild Cognitive Impairment or Dementia Only in APOE ɛ4 Allele Carriers.Semantic proximity Read ↗

Body mass index, genetic susceptibility, and Alzheimer's disease: a longitudinal study based on 475,813 participants from the UK Biobank.Semantic proximity Read ↗

Using a genetic risk score to estimate the earliest age of Alzheimer’s disease-related physiologic change in Body Mass IndexSemantic proximity Read ↗

Body Mass Index and Polygenic Risk for Alzheimer’s Disease Predict Conversion to Alzheimer’s DiseaseSemantic proximity Read ↗

The obesity paradox in cognitive decline: Impact of BMI dynamics and APOE genotypes across various cognitive status.Semantic proximity Read ↗

Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds.Semantic proximity Read ↗

Long-term dementia risk prediction by the LIBRA score: A 30-year follow-up of the CAIDE study.Semantic proximity Read ↗

Body mass index is associated with smaller medial temporal lobe volume in those at risk for Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.