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Article

A profile of impaired insulin degradation in relation to late-life cognitive decline: a preliminary investigation.

International journal of geriatric psychiatry - 1 Feb 2009

Okereke Olivia I, Selkoe Dennis J, Pollak Michael N, Stampfer Meir J, Hu Frank B, Hankinson Susan E, Grodstein Francine

Abstract excerpt

OBJECTIVE: Insulin degradation pathways may be related to Alzheimer's disease pathology. In preliminary analyses, we considered the relation of combined lower insulin secretion (c-peptide) and higher insulin--possibly a phenotype for impaired insulin degradation--to cognitive decline. METHOD: Fasting plasma c-peptide and insulin were measured in 1,187 non-diabetic Nurses' Health Study participants (mean age = 64...

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Source

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Identifiers

PMID: 18612998
DOI: 10.1002/gps.2089
PMCID: PMC2631087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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