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Article

Transcriptomic characterization of microglia activation in a rat model of ischemic stroke.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Dec 2020

Deng Wenjun, Mandeville Emiri, Terasaki Yasukazu, Li Wenlu, Holder Julie, Chuang Aaron Tt, Ning Mingming, Arai Ken, Lo Eng H, Xing Changhong

Abstract excerpt

Microglia are key regulators of inflammatory response after stroke and brain injury. To better understand activation of microglia as well as their phenotypic diversity after ischemic stroke, we profiled the transcriptome of microglia after 75 min transient focal cerebral ischemia in 3-month- and 12-month-old male spontaneously hypertensive rats. Microglia were isolated from the brains by FACS sorting on days 3...

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Identifiers

PMID: 33208001
DOI: 10.1177/0271678X20932870
PMCID: PMC7687036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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