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Article

Choosing the right mouse model: comparison of humanized NSG and NBSGW mice for in vivo HSC gene therapy

19 Dec 2023

Abstract excerpt

ABSTRACT: In vivo hematopoietic stem cell (HSC) gene therapy is an emerging and promising area of focus in the gene therapy field. Humanized mouse models are frequently used to evaluate novel HSC gene therapy approaches. Here, we comprehensively evaluated 2 mouse strains, NSG and NBSGW. We studied human HSC engraftment in the bone marrow (BM), mobilization of BM-engrafted HSCs into circulation, in vivo...

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PMID: 38113461
DOI: 10.1182/bloodadvances.2023011371

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