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Impact of amino acid substitutions in hepatitis C virus core region on the severe oxidative stress.

Free radical biology & medicine - 20 Feb 2024

Chida Takeshi, Watanabe Shinya, Ohta Kazuyoshi, Noritake Hidenao, Ito Masahiko, Suzuki Tetsuro, Suda Takafumi, Kawata Kazuhito

Abstract excerpt

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease, leading to liver steatosis, fibrosis, and hepatocellular carcinoma (HCC). Despite the accumulation of clinical data showing the impact of amino acid substitutions at positions 70 (R70Q/H) and/or 91 (L91M) in the HCV core protein in progressive liver diseases, including HCC, the underlying mechanisms have not been elucidated. We analyzed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38103659
DOI: 10.1016/j.freeradbiomed.2023.12.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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