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Article

Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1.

Journal of gastroenterology and hepatology - 1 Mar 2010

Pal Sampa, Polyak Stephen J, Bano Nazneen, Qiu Wan Chong, Carithers Robert L, Shuhart Margaret, Gretch David R, Das Aditi

Abstract excerpt

BACKGROUND AND AIMS: Hepatitis C virus (HCV)-induced chronic inflammation may induce oxidative stress which could compromise the repair of damaged DNA, rendering cells more susceptible to spontaneous or mutagen-induced alterations, the underlying cause of liver cirrhosis and hepatocellular carcinoma. In the current study we examined the induction of reactive oxygen species (ROS) resulting from HCV infection and...

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Source

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Identifiers

PMID: 20074151
DOI: 10.1111/j.1440-1746.2009.06128.x
PMCID: PMC3565844

Genes

NEIL1
NEIL2
OGG1

Provenance

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