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Article

Ethanol and reactive species increase basal sequence heterogeneity of hepatitis C virus and produce variants with reduced susceptibility to antivirals.

PloS one - 1 Jan 2011

Seronello Scott, Montanez Jessica, Presleigh Kristen, Barlow Miriam, Park Seung Bum, Choi Jinah

Abstract excerpt

Hepatitis C virus (HCV) exhibits a high level of genetic variability, and variants with reduced susceptibility to antivirals can occur even before treatment begins. In addition, alcohol decreases efficacy of antiviral therapy and increases sequence heterogeneity of HCV RNA but how ethanol affects HCV sequence is unknown. Ethanol metabolism and HCV infection increase the level of reactive species that can alter...

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Identifiers

PMID: 22087316
DOI: 10.1371/journal.pone.0027436
PMCID: PMC3210796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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