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Article

Upregulation of endoplasmic reticulum stress and reactive oxygen species by naturally occurring mutations in hepatitis B virus core antigen.

The Journal of general virology - 1 Jul 2015

Lee HyunJoo, Kim Hong, Lee Seoung-Ae, Won You-Sub, Kim Hye-In, Inn Kyung-Soo, Kim Bum-Joon

Abstract excerpt

Hepatitis B virus (HBV) infection is associated with a broad spectrum of clinical manifestations, including cirrhosis and hepatocellular carcinoma (HCC). Endoplasmic reticulum (ER) stress and subsequent oxidative stress have been implicated in liver carcinogenesis and disease progression with chronic inflammation. In our previous study, several mutations in the precore/core region of HBV genotype C were...

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Identifiers

PMID: 25828947
DOI: 10.1099/vir.0.000134

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