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Article

Plasma ctDNA is a tumor tissue surrogate and enables clinical-genomic stratification of metastatic bladder cancer.

Nature communications - 8 Jan 2021

Vandekerkhove Gillian, Lavoie Jean-Michel, Annala Matti, Murtha Andrew J, Sundahl Nora, Walz Simon, Sano Takeshi, Taavitsainen Sinja, Ritch Elie, Fazli Ladan, Hurtado-Coll Antonio, Wang Gang, Nykter Matti, Black Peter C, Todenhöfer Tilman, Ost Piet, Gibb Ewan A, Chi Kim N, Eigl Bernhard J, Wyatt Alexander W

Abstract excerpt

Molecular stratification can improve the management of advanced cancers, but requires relevant tumor samples. Metastatic urothelial carcinoma (mUC) is poised to benefit given a recent expansion of treatment options and its high genomic heterogeneity. We profile minimally-invasive plasma circulating tumor DNA (ctDNA) samples from 104 mUC patients, and compare to same-patient tumor tissue obtained during invasive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33420073
DOI: 10.1038/s41467-020-20493-6
PMCID: PMC7794518

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