Article
Novel EPHB4 Receptor Tyrosine Kinase Mutations and Kinomic Pathway Analysis in Lung Cancer.
Scientific reports - 15 Jun 2015
Ferguson Benjamin D, Carol Tan Yi-Hung, Kanteti Rajani S, Liu Ren, Gayed Matthew J, Vokes Everett E, Ferguson Mark K, John Iafrate A, Gill Parkash S, Salgia Ravi
Abstract excerpt
Lung cancer outcomes remain poor despite the identification of several potential therapeutic targets. The EPHB4 receptor tyrosine kinase (RTK) has recently emerged as an oncogenic factor in many cancers, including lung cancer. Mutations of EPHB4 in lung cancers have previously been identified, though their significance remains unknown. Here, we report the identification of novel EPHB4 mutations that lead to...
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