[SLCO1B1c. 521T>C gene polymorphisms are associated with high-dose methotrexate pharmacokinetics and clinical outcome of pediatric acute lymphoblastic leukemia].

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[SLCO1B1c. 521T>C gene polymorphisms are associated with high-dose methotrexate pharmacokinetics and clinical outcome of pediatric acute lymphoblastic leukemia].

Zhonghua er ke za zhi = Chinese journal of pediatrics - 1 Oct 2014

Zhang Huanian, He Xuelian, Li Jianxin, Wang Yang, Wang Cheng, Chen Yujun, Niu Changhe, Gao Ping

Abstract excerpt

OBJECTIVE: To provide guidance for the high-dose methotrexate (HD-MTX) treatment of pediatric acute lymphoblastic leukemia (ALL), and to understand the impact of SLCO1B1c.521T>C (rs4149056) variant on methotrexate (MTX) pharmacokinetics and clinical outcome in children with ALL. METHOD: Eighty-two children with ALL in Division of Hematology of Wuhan Children's Hospital from January 2008 to February 2013 were...

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PMID: 25537545

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