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Article

The Role of Candidate Polymorphisms in Drug Transporter Genes on High-Dose Methotrexate in the Consolidation Phase of the AIEOP-BFM ALL 2009 Protocol.

Clinical and translational science - 1 Feb 2025

Braidotti Stefania, Zudeh Giulia, Franca Raffaella, Kiren Valentina, Colombini Antonella, Bettini Laura Rachele, Brivio Erica, Locatelli Franco, Vinti Luciana, Bertorello Nicoletta, Fagioli Franca, Silvestri Daniela, Valsecchi Maria Grazia, Decorti Giuliana, Stocco Gabriele, Rabusin Marco

Abstract excerpt

High-dose methotrexate (HD-MTX) infusions are commonly used to consolidate remission in children with acute lymphoblastic leukemia (ALL). We investigate the potential role of candidate polymorphisms in SLCO1B1 (rs4149056 and rs2306283), ABCB1 (rs1045642), ABCC2 (rs717620), ABCC3 (rs9895420), and ABCC4 () drug transporters genes on HD-MTX pharmacokinetics and patients' outcome (meant both as relapse and...

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Share to Antimetabolites, Antineoplastic
Share to Antineoplastic Combined Chemotherapy Protocols
Share to ATP Binding Cassette Transporter, Subfamily B
Share to Liver-Specific Organic Anion Transporter 1
Share to Methotrexate
Share to Multidrug Resistance-Associated Protein 2
Share to Pharmacogenomic Variants
Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Open in PubMed Open full text

Identifiers

PMID: 39891427
DOI: 10.1111/cts.70136
PMCID: PMC11786019

Genes

ABCC2
ABCC4
SLCO1B1
ABCB1
ABCC3

Variants

rs4149056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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The Role of Candidate Polymorphisms in Drug Transporter Genes on High-Dose Methotrexate in the Consolidation Phase of the AIEOP-BFM ALL 2009 Protocol.PMID 39891427Read ↗

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