Article

Helmsman: fast and efficient generation of input matrices for mutation signature analysis

2018-07-20

Abstract excerpt

<h4>Motivation</h4> The spectrum of somatic single-nucleotide variants in cancer genomes often reflects the signatures of multiple distinct mutational processes, which can provide clinically actionable insights into cancer etiology. Existing software tools for identifying and evaluating these mutational signatures do not scale to analyze large datasets containing thousands of individuals or millions of variants....

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Literature Corpus work: 22126770-c4c3-5f6f-97c5-4a6c2acc86ae
DOI: 10.1101/373076

Open publication

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