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Sigflow: an automated and comprehensive pipeline for cancer genome mutational signature analysis.

Bioinformatics (Oxford, England) - 12 Jul 2021

Wang Shixiang, Tao Ziyu, Wu Tao, Liu Xue-Song

Abstract excerpt

SUMMARY: Mutational signatures are recurring DNA alteration patterns caused by distinct mutational events during the evolution of cancer. In recent years, several bioinformatics tools are available for mutational signature analysis. However, most of them focus on specific type of mutation or have limited scope of application. A pipeline tool for comprehensive mutational signature analysis is still lacking. Here...

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PMID: 33270873
DOI: 10.1093/bioinformatics/btaa895
PMCID: PMC8275980

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