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Selection of phage‐displayed llama single‐domain antibodies that transmigrate across human blood‐brain barrier endothelium

28 Dec 2001

Abstract excerpt

Delivery to the brain of drugs, peptides, and genes depends on the availability of brain-specific delivery vectors. We used a phage-displayed library of llama single-domain antibodies (sdAbs) to enrich for species that selectively bind to and are internalized by human cerebromicrovascular endothelial cells (HCEC). Two sdAbs (FC5 and FC44) were selected, sequenced, subcloned, and expressed as fusion proteins with...

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Share to Advanced biosensing and bioanalysis techniques
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PMID: 11772942
DOI: 10.1096/fj.01-0343fje

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