Article
Distinct Hodgkin lymphoma subtypes defined by noninvasive genomic profiling.
Nature - 1 Jan 2024
Alig Stefan K, Shahrokh Esfahani Mohammad, Garofalo Andrea, Li Michael Yu, Rossi Cédric, Flerlage Tim, Flerlage Jamie E, Adams Ragini, Binkley Michael S, Shukla Navika, Jin Michael C, Olsen Mari, Telenius Adèle, Mutter Jurik A, Schroers-Martin Joseph G, Sworder Brian J, Rai Shinya, King Daniel A, Schultz Andre, Bögeholz Jan, Su Shengqin, Kathuria Karan R, Liu Chih Long, Kang Xiaoman, Strohband Maya J, Langfitt Deanna, Pobre-Piza Kristine Faye, Surman Sherri, Tian Feng, Spina Valeria, Tousseyn Thomas, Buedts Lieselot, Hoppe Richard, Natkunam Yasodha, Fornecker Luc-Matthieu, Castellino Sharon M, Advani Ranjana, Rossi Davide, Lynch Ryan, Ghesquières Hervé, Casasnovas Olivier, Kurtz David M, Marks Lianna J, Link Michael P, André Marc, Vandenberghe Peter, Steidl Christian, Diehn Maximilian, Alizadeh Ash A
Abstract excerpt
The scarcity of malignant Hodgkin and Reed-Sternberg cells hampers tissue-based comprehensive genomic profiling of classic Hodgkin lymphoma (cHL). By contrast, liquid biopsies show promise for molecular profiling of cHL due to relatively high circulating tumour DNA (ctDNA) levels1-4. Here we show that the plasma representation of mutations exceeds the bulk tumour representation in most cases, making cHL...
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