Circulating tumor DNA reveals genetics, clonal evolution, and residual disease in classical Hodgkin lymphoma.

doi:10.1182/blood-2017-11-812073

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Circulating tumor DNA reveals genetics, clonal evolution, and residual disease in classical Hodgkin lymphoma.

Blood - 31 May 2018

Spina Valeria, Bruscaggin Alessio, Cuccaro Annarosa, Martini Maurizio, Di Trani Martina, Forestieri Gabriela, Manzoni Martina, Condoluci Adalgisa, Arribas Alberto, Terzi-Di-Bergamo Lodovico, Locatelli Silvia Laura, Cupelli Elisa, Ceriani Luca, Moccia Alden A, Stathis Anastasios, Nassi Luca, Deambrogi Clara, Diop Fary, Guidetti Francesca, Cocomazzi Alessandra, Annunziata Salvatore, Rufini Vittoria, Giordano Alessandro, Neri Antonino, Boldorini Renzo, Gerber Bernhard, Bertoni Francesco, Ghielmini Michele, Stüssi Georg, Santoro Armando, Cavalli Franco, Zucca Emanuele, Larocca Luigi Maria, Gaidano Gianluca, Hohaus Stefan, Carlo-Stella Carmelo, Rossi Davide

Abstract excerpt

The rarity of neoplastic cells in the biopsy imposes major technical hurdles that have so far limited genomic studies in classical Hodgkin lymphoma (cHL). By using a highly sensitive and robust deep next-generation sequencing approach for circulating tumor DNA (ctDNA), we aimed to identify the genetics of cHL in different clinical phases, as well as its modifications on treatment. The analysis was based on...

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PMID: 29449275
DOI: 10.1182/blood-2017-11-812073

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