Circulating Tumor DNA Sequencing for Biologic Classification and Individualized Risk Stratification in Patients With Hodgkin Lymphoma.

doi:10.1200/JCO.23.01867

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Article

Circulating Tumor DNA Sequencing for Biologic Classification and Individualized Risk Stratification in Patients With Hodgkin Lymphoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Dec 2024

Heger Jan-Michel, Mammadova Laman, Mattlener Julia, Sobesky Sophia, Cirillo Melita, Altmüller Janine, Kirst Elisabeth, Reinke Sarah, Klapper Wolfram, Bröckelmann Paul J, Ferdinandus Justin, Kaul Helen, Schneider Gundolf, Schneider Jessica, Schleifenbaum Julia Katharina, Ullrich Roland T, Freihammer Max, Awerkiew Sabine, Lohmann Mia, Klein Florian, Nürnberg Peter, Hallek Michael, Rossi Davide, Mauz-Körholz Christine, Gattenlöhner Stefan, Bräuninger Andreas, Borchmann Peter, von Tresckow Bastian, Borchmann Sven

Abstract excerpt

PURPOSE: Current clinical challenges in Hodgkin lymphoma (HL) include difficult-to-treat relapsed/refractory disease and considerable long-term toxicities of treatment. Since clinical risk factors lack discriminatory power, intensity of therapy is mainly based on tumor burden. Exploring HL genetics and tumor microenvironment (TME) might provide valuable insights for improved risk stratification. MATERIALS AND...

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Identifiers

PMID: 39348625
DOI: 10.1200/JCO.23.01867

Genes

C2
ITPKB
SOCS1
TNFAIP3

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