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Article

Circulating tumor DNA in Hodgkin lymphoma.

Annals of hematology - 1 Nov 2022

Maco Maria, Kupcova Kristyna, Herman Vaclav, Ondeckova Iva, Kozak Tomas, Mocikova Heidi, Havranek Ondrej

Abstract excerpt

Somatic mutations of genes involved in NF-κB, PI3K/AKT, NOTCH, and JAK/STAT signaling pathways play an important role in the pathogenesis of Hodgkin lymphoma (HL). HL tumor cells form only about 5% of the tumor mass; however, it was shown that HL tumor-derived DNA could be detected in the bloodstream. This circulating tumor DNA (ctDNA) reflects the genetic profile of HL tumor cells and can be used for qualitative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36074181
DOI: 10.1007/s00277-022-04949-x
PMCID: PMC9546971

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