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Tumor-microenvironment and molecular biology of classic Hodgkin lymphoma in children, adolescents, and young adults

1 May 2025

Abstract excerpt

Classic Hodgkin lymphoma (cHL) exhibits a bimodal age distribution with incidence peaks in adolescents and young adults (AYAs) aged 15-39 years and in older adults over 50 years. The unique biology of cHL, characterized by a tumor microenvironment (TME) composed predominantly of non-malignant immune and stromal cells, plays a pivotal role in supporting Hodgkin and Reed-Sternberg (HRS) cells, the malignant cells...

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PMID: 40376590
DOI: 10.3389/fonc.2025.1515250

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