Article

Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma

2021-07-04

Abstract excerpt

The malignant Hodgkin and Reed Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) are scarce in affected lymph nodes, creating a challenge to detect driver somatic mutations. As an alternative to cell purification techniques, we hypothesized that ultra-deep exome sequencing would allow genomic study of HRS cells, thereby streamlining analysis and avoiding technical pitfalls. To test this, 31 cHL tumor/norma...

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Literature Corpus work: 54eb1d10-b7a1-5ec3-814e-56196bf4facf
DOI: 10.1101/2021.06.25.21258374

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