Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Androgen signaling stabilizes genomes to counteract senescence by promoting XRCC4 transcription

13 Nov 2023

Abstract excerpt

Aging is accompanied by a decreased DNA repair capacity, which might contribute to age-associated functional decline in multiple tissues. Disruption in hormone signaling, associated with reproductive organ dysfunction, is an early event of age-related tissue degeneration, but whether it impacts DNA repair in nonreproductive organs remains elusive. Using skin fibroblasts derived from healthy donors with a broad...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Genomics and Chromatin Dynamics
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37955230
DOI: 10.15252/embr.202356984

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Androgen signaling stabilizes genomes to counteract senescence by promoting XRCC4 transcriptionPMID 37955230Read ↗

Enhancing DNA Repair Prolongs Lifespan and Improves Healthspan in MiceSemantic proximity Read ↗

Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human donorsSemantic proximity Read ↗

DNA damage response at telomeres boosts the transcription of SARS‐CoV‐2 receptor ACE2 during agingSemantic proximity Read ↗

Base excision repair but not DNA double‐strand break repair is impaired in aged human adipose‐derived stem cellsSemantic proximity Read ↗

Sex-specific differences in DNA double-strand break repair of cycling human lymphocytes during agingSemantic proximity Read ↗

Histone deacetylase 4 reverses cellular senescence via DDIT4 in dermal fibroblastsSemantic proximity Read ↗

SIRT1 mediates KU70 to maintain Genomic Stability in Spermatogonial Stem Cells via NHEJ Repair pathwaySemantic proximity Read ↗

Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescenceSemantic proximity Read ↗

SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent mannerSemantic proximity Read ↗

Suppression of the DHX9 Helicase Induces Premature Senescence in Human Diploid Fibroblasts in a p53-dependent MannerSemantic proximity Read ↗

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.Semantic proximity Read ↗

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcriptionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.