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Comet assay for quantification of the increased <scp>DNA</scp> damage burden in primary human chondrocytes with aging and osteoarthritis

22 Aug 2022

Abstract excerpt

Abstract It is known that chondrocytes from joints with osteoarthritis (OA) exhibit high levels of DNA damage, but the degree to which chondrocytes accumulate DNA damage during “normal aging” has not been established. The goal of this study was to quantify the DNA damage present in chondrocytes obtained from cadaveric donors of a wide age range, and to compare the extent of this damage to OA chondrocytes. The...

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PMID: 35996812
DOI: 10.1111/acel.13698

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