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Article

Progressive replacement of embryo-derived cardiac macrophages with age.

The Journal of experimental medicine - 20 Oct 2014

Molawi Kaaweh, Wolf Yochai, Kandalla Prashanth K, Favret Jeremy, Hagemeyer Nora, Frenzel Kathrin, Pinto Alexander R, Klapproth Kay, Henri Sandrine, Malissen Bernard, Rodewald Hans-Reimer, Rosenthal Nadia A, Bajenoff Marc, Prinz Marco, Jung Steffen, Sieweke Michael H

Abstract excerpt

Cardiac macrophages (cMΦ) are critical for early postnatal heart regeneration and fibrotic repair in the adult heart, but their origins and cellular dynamics during postnatal development have not been well characterized. Tissue macrophages can be derived from embryonic progenitors or from monocytes during inflammation. We report that within the first weeks after birth, the embryo-derived population of resident...

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Source

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Identifiers

PMID: 25245760
DOI: 10.1084/jem.20140639
PMCID: PMC4203946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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