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Vincristine Disposition and Neurotoxicity Are Unchanged in Humanized CYP3A5 Mice.

Drug metabolism and disposition: the biological fate of chemicals - 9 Jan 2024

Li Yang, Kazuki Yasuhiro, Drabison Thomas, Kobayashi Kaoru, Fujita Ken-Ichi, Xu Yue, Jin Yan, Ahmed Eman, Li Junan, Eisenmann Eric D, Baker Sharyn D, Cavaletti Guido, Sparreboom Alex, Hu Shuiying

Abstract excerpt

Previous studies have suggested that the incidence of vincristine-induced peripheral neuropathy (VIPN) is potentially linked with cytochrome P450 (CYP)3A5, a polymorphic enzyme that metabolizes vincristine in vitro, and with concurrent use of azole antifungals such as ketoconazole. The assumed mechanism for these interactions is through modulation of CYP3A-mediated metabolism, leading to decreased vincristine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38071551
DOI: 10.1124/dmd.123.001466
PMCID: PMC10801630

Genes

CYP3A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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