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Impact of plasma and intracellular exposure and CYP3A4, CYP3A5, and ABCB1 genetic polymorphisms on vincristine-induced neurotoxicity.

Cancer chemotherapy and pharmacology - 1 Dec 2011

Guilhaumou Romain, Solas Caroline, Bourgarel-Rey Veronique, Quaranta Sylvie, Rome Angelique, Simon Nicolas, Lacarelle Bruno, Andre Nicolas

Abstract excerpt

PURPOSE: The aim of this study was to investigate the impact of plasma and intracellular exposure and CYP3A4, CYP3A5, and ABCB1 polymorphisms on vincristine neurotoxicity. We subsequently assessed the impact of ABCB1 polymorphisms on intracellular vincristine accumulation. METHODS: Children treated for solid tumors were enrolled in the study (n = 26) and received 1.5 mg/m² of vincristine per course. Individual...

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Identifiers

PMID: 21968951
DOI: 10.1007/s00280-011-1745-2

Genes

ABCB1

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