Extrapolating Vincristine-Induced Peripheral Neuropathy From Caucasian to Kenyan Populations: Impact of Type I and Type II Selection Bias.

Abstract excerpt

Vincristine is a cornerstone of pediatric chemotherapy, but its use is limited by vincristine-induced peripheral neuropathy (VIPN). Paradoxically, African children tolerate higher vincristine doses with minimal neurotoxicity, raising questions about the pharmacological mechanisms and model generalizability across populations. In this study, we re-estimated vincristine pharmacokinetic (PK) and PK-pharmacodynamic...

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