Article
Genetic factors influencing the development of vincristine-induced neurotoxicity.
Expert opinion on drug metabolism & toxicology - 1 Feb 2021
Pozzi Eleonora, Fumagalli Giulia, Chiorazzi Alessia, Canta Annalisa, Cavaletti Guido
Abstract excerpt
Introduction: One of the most common side effects during vincristine (VCR) use is the establishment of VCR-induced peripheral neuropathy (VIPN). Among several risk factors that can influence the development of VIPN, such as cumulative dose and patient's age, sex, ethnicity, and genetic variants, this review is focused on the genetic variability. Areas covered: A literature research was performed firstly using the...
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