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Article

Association of CYP3A5 Expression and Vincristine Neurotoxicity in Pediatric Malignancies in Turkish Population.

Journal of pediatric hematology/oncology - 1 Aug 2017

Kayilioğlu Hülya, Kocak Ulker, Kan Karaer Derya, Percin Emriye F, Sal Ertan, Tekkesin Funda, Isik Melek, Oner Nergiz, Belen Fatma B, Yilmaz Keskin Ebru, Okur Arzu, Albayrak Meryem, Kaya Zuhre, Pinarli Faruk G, Yenicesu Idil, Karadeniz Ceyda, Oguz Aynur, Gursel Turkiz

Abstract excerpt

Vincristine is a widely used chemotherapeutic agent in the treatment of childhood malignancies. Neuropathy is the most common adverse effect. CYP3A4 and CYP3A5 enzymes of cytochrome p450 enzyme system are responsible in vincristine metabolism. Genetic polymorphism may alter the vincristine metabolism and the neurotoxicity rate. In this study, distribution of CYP3A5 alleles among Turkish children with...

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Share to Antineoplastic Agents, Phytogenic
Share to Cytochrome P-450 CYP3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

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Identifiers

PMID: 28697165
DOI: 10.1097/MPH.0000000000000910

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