Article

Analysis of uveal melanoma scRNA sequencing data identifies neoplastic-immune hybrid cells that exhibit metastatic potential

2023-10-27

Abstract excerpt

Uveal melanoma (UM) is the most common non-cutaneous melanoma and is an intraocular malignancy that affects nearly 7,000 individuals per year worldwide. Of these, nearly 50% will progress to metastatic disease for which there are currently no effective therapies. Despite advances in the molecular profiling and metastatic stratification of class 1 and 2 UM tumors, little is known regarding the underlying biology of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: df6a72c4-bbac-5e00-8aff-6e540f389be8
DOI: 10.1101/2023.10.24.563815

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Analysis of uveal melanoma scRNA sequencing data identifies neoplastic-immune hybrid cells that exhibit metastatic potentialDOI 10.1101/2023.10.24.563815Read

Detection of neoplastic-immune hybrid cells with metastatic properties in uveal melanomaSemantic proximity Read

Delineating the early dissemination mechanisms of acral melanoma by integrating single-cell and spatial transcriptomic analysesSemantic proximity Read

Patient-derived xenografts and single-cell sequencing identifies three subtypes of tumor-reactive lymphocytes in uveal melanoma metastasesSemantic proximity Read

Integrated analysis reveals the dysfunction of signaling pathways in uveal melanomaSemantic proximity Read

Single-cell analysis reveals new evolutionary complexity in uveal melanomaSemantic proximity Read

Molecular profiling of driver events and tumor-infiltrating lymphocytes in metastatic uveal melanomaSemantic proximity Read

Machine Learning and Single-Cell RNA Sequencing Reveal Relationship Between Intratumor CD8 + T Cells and Uveal Melanoma MetastasisSemantic proximity Read

Recent Advances in Molecular and Genetic Research on Uveal Melanoma.Semantic proximity Read

Heterogeneity and molecular landscape of melanoma: implications for targeted therapy.Semantic proximity Read

Single-cell hdWGCNA reveals Metastatic protective macrophages and development of deep learning model in uveal melanomaSemantic proximity Read

Single-cell analysis unveils cell subtypes of acral melanoma cells at the early and late differentiation stagesSemantic proximity Read

The Tongren-Ophthalmology Research Association of Clinical Evaluation - Uveal Melanoma (TRACE-UM): Objectives, Design, Current Results, and OutlookSemantic proximity Read