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Article

Population Pharmacokinetics of Dapoxetine in Healthy Chinese Male Subjects.

Journal of clinical pharmacology - 1 Feb 2026

Pu Libin, Wu Tong, Bai Fuqiang, Lu Haobo, Wang Yiming, Gao Yuan, Qiu Wen

Abstract excerpt

Dapoxetine is a short-acting selective serotonin reuptake inhibitor used to treat premature ejaculation. However, its clinical effectiveness is challenged by substantial inter-individual variability in pharmacokinetics, as both the drug's therapeutic efficacy and the incidence of adverse reactions are highly dependent on its exposure. This study aims to develop a population pharmacokinetic model for dapoxetine,...

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Source

Identifiers

PMID: 41031519
DOI: 10.1002/jcph.70117

Genes

CYP3A4
CYP3A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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