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A neurodegeneration gene, WDR45, links impaired ferritinophagy to iron accumulation

27 Nov 2021

Abstract excerpt

Neurodegeneration with brain iron accumulation (NBIA) is a clinically and genetically heterogeneous group of neurodegenerative diseases characterized by the abnormal accumulation of brain iron and the progressive degeneration of the nervous system. One of the recently identified subtypes of NBIA is β-propeller protein-associated neurodegeneration (BPAN). BPAN is caused by de novo mutations in the WDR45/WIPI4 (WD...

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PMID: 34837396
DOI: 10.1111/jnc.15548

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A neurodegeneration gene, WDR45, links impaired ferritinophagy to iron accumulationPMID 34837396Read ↗

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